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Current available literature about the effects of liming on some soil biota such as fungi, nematodes and earthworms are sparse, and sometimes contradictory
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177,178 It is a pleiotropic metabolic disorder, and patients present in the neonatal or antenatal period with dysmorphic features, hepatosplenomegaly, abnormal liver function, cardiac defects, thrombocytopenia, bleeding tendencies, and anemia